Treatment
The prognosis for malignant mesothelioma remains disappointing,
although there have been some modest improvements in prognosis from
newer chemotherapies and multimodality treatments.
[29]
Treatment of malignant mesothelioma at earlier stages has a better
prognosis, but cures are exceedingly rare. Clinical behavior of the
malignancy is affected by several factors including the continuous
mesothelial surface of the pleural cavity which favors local metastasis
via exfoliated cells, invasion to underlying tissue and other organs
within the pleural cavity, and the extremely long latency period between
asbestos exposure and development of the disease. The histological
subtype and the patient's age and health status also help predict
prognosis. The epithelioid histology responds better to treatment and
has a survival advantage over sarcomatoid histology.
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